Reference numberEC/1978/07
Previous numbersCert XX, 96
TitleCohen, Sydney: certificate of election to the Royal Society
DescriptionCitation typed
CitationCohen has made a series of important contributions to the understanding of immunity. Commencing with metabolic studies, he provided the first quantitative data on the distribution and turnover of IgC and IgM in human subjects. Turning to structural studies he showed that the light chains were common to all classes of immunoglobulin but that light chains of the normal proteins were hetergeneous (sic) in contrast to those of monoclonal proteins. Perhaps of greatest significance is the work with malaria. Cogen (with McGregor) showed for the first time, that immunity could be passively transferred with immune IgG. An in vitro assay was devised for analysing the mechanism of malaria immunity and the variant specificity of protective antibody was demonstrated. This has provided a means of isolating malarial antigens and free merozoites and for analysing the basis of host specificity. A practical method has resulted for screening anti-malarial drugs. The work has throughout been characterised by its originality and technical skill.
Access statusClosed
Fellows associated with this archive
NA4365Cohen; Sydney (1921 - 2017)1921 - 2017
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