| RefNo | EC/1959/23 |
| Previous numbers | Cert XVI, 259; A56556 |
| Level | Item |
| Title | Tait, Sylvia Agnes Sophia: certificate of election to the Royal Society |
| Description | Certificate of Election |
| Citation | From 1948 to 1951, S.A.S. Tait with J.F. Tait, developed a bioassay method which measured the effects of adrenal hormones on mineral metabolism. The potency of all known hormones was measured by this method and compared with that of a commercial preparation of adrenal extract. This was found to be more potent that could be explained by the amounts of known hormones present unless synergism occurred. It was shown that the compound responsible for this biological activity, later named aldosterone, could be completely separated from known hormones. It was 120 x more active than deoxycorticosterone in the 24Na/K42 test, 0.01 micrograms per animal being detectable and this made possible the measurement of the hormone in various biological extracts, although the amounts present were extremely small (50 micrograms per HG adrenal glands). The use of the bioassay method enabled S.A.S. Tait, together with J.F. Tait, to investigate the behaviour of aldosterone in various chromatographic systems which led to the crystallisation of the hormone by these workers with the teams of T. Reichstein and A. Wettstein. |
| Proposers | From Personal Knowledge: E C Dodds; F G Young; G F Marrian; F Dickens; S J Folley; A S Parkes; G W Harris |
| AccessStatus | Open |
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Fellows associated with this archive
| Code | PersonName | Dates |
| NA306 | Tait; Sylvia Agnes Sophia (1917 - 2003) | 1917 - 2003 |