Record

RefNoEC/1993/19
LevelItem
TitleJacobs, Patricia Ann: certificate of election to the Royal Society
Date1987
DescriptionCitation typed
CitationDistinguished for her outstanding contributions to human cytogenetics. As a member of the MRC Clinical and Population Cytogenetics Unit, she played a leading role in elucidating the chromosomal basis of abnormalities of sexual development, including the XXY Klinefelter karyotype, XXX women, XYY men, and the XY status of women with the androgen insensitivity syndrome (testicular feminization). By comparing the phenotypic effects of various Y chromosome abnormalities she inferred correctly that the "masculinizing" factor was located on the short arm of the human Y chromosome. By determining the incidence of structural rearrangements in a series of more than 10,000 unselected newborn infants, she was able to derive mutation rates, and in collaboration with Newton Morton to estimate the reproductive fitness of heterozygotes. In a later study of marker chromosomes in spontaneously aborted trisomic and triploid embryos, she succeeded in identifying the source of the extra chromosome or chromosome set. She was instrumental in devising the first method of karyotyping individual spermatozoa. Recently she has elucidated the androgenetic origin of a large series of hydatidiform moles, and has carried out extensive studies of the "fragile-X" chromosome.
AccessStatusClosed
Add to My Items

    Collection highlights

    Browse the records of some of our collections, which cover all branches of science and date from the 12th century onwards. These include the published works of Fellows of the Royal Society, personal papers of eminent scientists, letters and manuscripts sent to the Society or presented at meetings, and administrative records documenting the Society's activities since our foundation in 1660.

    The Royal Society

    The Royal Society is a Fellowship of many of
    the world's most eminent scientists and is the
    oldest scientific academy in continuous existence.
    Registered charity number 207043

    Website design ©CalmView



    CONTACT US

    + 44 207 451 2500
    (Lines open Mon-Fri, 9:00-17:00. Excludes bank holidays)

    6-9 Carlton House Terrace, London SW1Y 5AG

    Email Us →

    SUBSCRIBE

    Subscribe to our newsletters to be updated with the
    latest news on innovation, events, articles and reports.

    Subscribe →

    © CalmView