| Citation | Distinguished for his analysis of eukaryotic DNA replication. He has used cell-free DNA replication systems to identify and characterize cellular proteins which are required for viral DNA replication and thus implicated in cellular DNA replication. He showed that DNA polymerase delta is fully involved in DNA replication, synthesizing the leading strand at a fork. He identified and characterized other replication proteins including RF-A (now called RP-A) and RF-C. He identified and characterized a human chromatin assembly factor which assembles nucleosomes inn a replication-dependent reaction. His most recent discovery of an origin recognition complex in yeast is a major landmark in studies of eukaryotic DNA replication. |