Homepage

Record

RefNoEC/1996/37
LevelItem
TitleSutherland, Grant Robert: certificate of election to the Royal Society
Date1995
DescriptionCitation typed
CitationDistinguished for his pioneering work on fragile sites in human chromosomes and his discovery of trinocleotide repeat instability as a novel mechanism for human genetic disease. He was the first to show that fragile site expression in lymphocytes could be influenced by cell culture conditions, in particular withdrawal of folic acid, and used this discovery to develop reliable cytogenetic methods for detecting rare folate-sensitive fragile sites, including that for fragile X syndrome, the most common form of familial mental retardation. He was the first to clone the fragile X locus and to show that both the fragile site and mental retardation resulted from remarkable instability in a (CGG)n trinucleotide repeat array. He further showed that (CGG)n repeat instability was also responsible for an autosomal fragile site. His discovery of triplet repeat "dynamic mutation" has not only clarified the unusual genetics of fragile X mental retardation, but has opened up a much wider new field in human genetics and has provided the conceptual basis for identifying loci involved in other neurological diseases, including Huntington's chorea and myotonic dystrophy, which result from dynamic mutation.
AccessStatusClosed
Add to My Items
    Botanical paintings by Jacob van Huysum and William Sartorius

    Botanical paintings by Jacob van Huysum and William Sartorius

    Useful Links

    Collection highlights

    Browse the records of some of our collections, which cover all branches of science and date from the 12th century onwards. These include the published works of Fellows of the Royal Society, personal papers of eminent scientists, letters and manuscripts sent to the Society or presented at meetings, and administrative records documenting the Society's activities since our foundation in 1660.

    Classified Papers
    Classified Papers
    Referees’ Reports
    Referees’ Reports
    Botanical paintings by Jacob van Huysum and William Sartorius
    Botanical paintings by Jacob van Huysum and William Sartorius
    Papers of Colin Pillinger
    Papers of Colin Pillinger
    Browse Collections

    The Royal Society

    The Royal Society is a Fellowship of many of
    the world's most eminent scientists and is the
    oldest scientific academy in continuous existence.
    Registered charity number 207043

    Website design ©CalmView



    CONTACT US

    + 44 207 451 2500
    (Lines open Mon-Fri, 9:00-17:00. Excludes bank holidays)

    6-9 Carlton House Terrace, London SW1Y 5AG

    Email Us →

    SUBSCRIBE

    Subscribe to our newsletters to be updated with the
    latest news on innovation, events, articles and reports.

    Subscribe →

    © CalmView