Citation | Patrick Tam is cited for his research into cell fate and cell lineage in mammalian development. [Crossed out on Certificate: Using combinations of cell marking and cell transplantation in early postimplantation embryos in culture, he has defined the fate map of the gastrulating mouse embryo in exquisite detail.] He also proved experimentally that mammalian germ cells arise by induction rather than segregation of germ plasm as in other species and showed that the mammalian organizer, which induces the body axis, varies in composition and inductive ability over time. These studies, and his many other contributions, have been fundamentally important for understanding early embryonic development and origins of congenital malformations. |