Record

Authorised form of nameMacLennan; David Herman (1937 - 2020)
Dates1937 - 2020
NationalityCanadian
Place of birthSwan River, Manitoba, Canada, North and Central America
Date of birth03/07/1937
Date of death24/06/2020
OccupationBiochemist
Research fieldGenetics; medical research; proteins
ActivityEducation:
University of Manitoba, BSA (1959), DSc (2001); Purdue University, MS (1961), PhD (1963),
Career:
University of Wisconsin, Postdoctoral Fellow (1963-1964), Assistant Professor (1964-1968); Banting and Best Department of Medical Research, University of Toronto, Associate Professor (1969), Professor (1974), Chair (1978-1990), J. W. Billes Professor of Medical Research (1987-2007), University Professor (1993-2015)
Honours:
Officer of the Order of Canada 2001; Member of the Order of Ontario 2009
Memberships:
Royal Society of Canada (1985); US National Academy of Sciences (2001); International Society for Heart Research (2001); Japanese Biochemical Society (2004); American Academy of Arts and Sciences (2015)
Medals/Awards:
Ayerst Award of the Canadian Biochemical Society 1974; National Lecturer Award of the Biophysical Society 1990; Gairdner Foundation International Award 1991; Killam Prize (Health Sciences) of the Canada Council for the Arts 1997; Canadian Medical Hall of Fame 2013
Membership categoryFellow
Date of election10/03/1994
Age at election56
Royal Society activityMedals and prizes:
Glaxo Wellcome 2000
Lectures:
Glaxo Wellcome 2000
Published workshttp://worldcat.org/identities/np-maclennan,%20david%20h/
General contextDavid MacLennan is a biochemist best known for his work on the proteins that regulate the flow, or flux, of calcium through the sarcoplasmic reticulum — thereby regulating muscle contraction and relaxation. His findings have led to important discoveries in the field of muscle diseases caused by genetic defects in calcium regulatory proteins.

He developed a structural model for the relevant calcium pump based upon its amino acid sequence and the properties of over 250 altered pumps created using the technique of site-directed mutagenesis. Studies of these mutants led to new insight into the pump’s mechanism and provided an improved understanding of the genetic basis for human skeletal muscle conditions such as Brody myopathy and malignant hyperthermia.

David has been elected as a Fellow of a number of prestigious international societies and received many awards, including the Canada Gairdner International Award in 1991 and the Killam Prize of the Canada Council for the Arts in 1997. He became an Officer of the Order of Canada in 2001.

Professor David MacLennan OC FRS died on 24 June 2020.
SourcesSources:
https://royalsociety.org/people/david-maclennan-11861/ (accessed 22 July 2020); Wikipedia
Royal Society codeNA7892
Archives associated with this Fellow
Reference numberTitleDate
IM/002893MacLennan, David Herman1994
EC/1994/24MacLennan, David Herman: certificate of election to the Royal Society08/07/1991
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