Paper, 'An account of a person who took a great quantity of opium without causing sleep' by Francis Willis, Stephen Flavell, John Cooke, and Richard Fanner The paper describes the case of a woman who, taken by fever, was given various quantities of opium in order to induce sleep from 28 January to 31 January 1701. The opium did not make her sleepy, but rather 'refreshed' her. She the died on 1 February 1701. The account is signed by Dr Franc [Francis] Willis of Oxford, Dr Step [Stephen] Flavell, Dr John Cooke, and Ri [Richard] Fanner in the presence of Rich [Richard] Smith, Rich [Richard] Spicer, and Rogr [Roger] Garnham. Subject: Medicine / Pharmacy Published in Philosophical Transactions as 'An account of a person who took a great quantity of opium, without causing sleep'. Dated at Newberry [Newbury]. Read to the Royal Society on 9 April 1701. 28 January 1701