Paper, 'The influence of intra-venous injection of sugar on the gases of the blood' by Vaughan Harley Harley writes: 'In a paper on “The Effects and Chemical Changes of Sugar injected into a Vein” [see PP/22/14] I showed that when grape sugar is injected into the jugular vein of a dog it causes an augmentation in the quantity of lactic acid in the circulation, the quantity of the acid steadily increasing until it reaches its maximum in about three hours after the injection. It then gradually, hour by hour, decreases, until in about six hours it returns to the normal amount. The question as to the base with which the lactic acid combines to form a lactate is, however, still unsettled.' Annotations in pencil and ink. Subject: Physiology / Biology Received 9 May 1894 / 11 May 1894. Read 7 June 1894. Communicated by George Harley. A version of this paper was published in volume 56 of the Proceedings of the Royal Society as 'The influence of intra-venous injection of sugar on the gases of the blood'. 1894