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  <PersonName label="Authorised form of name" urlencoded="Chambers%3b+Richard+Dickinson+(1935+-+2019)" urlpathencoded="Chambers;%20Richard%20Dickinson%20(1935%20-%202019)">Chambers; Richard Dickinson (1935 - 2019)</PersonName>
  <Surname label="Surname" urlencoded="Chambers" urlpathencoded="Chambers">Chambers</Surname>
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  <Dates label="Dates" urlencoded="1935+-+2019" urlpathencoded="1935%20-%202019">1935 - 2019</Dates>
  <Nationality label="Nationality" urlencoded="British" urlpathencoded="British">British</Nationality>
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  <PlaceOfBirth label="Place of birth" urlencoded="West+Stanley%2c+Co+Durham%2c+England" urlpathencoded="West%20Stanley,%20Co%20Durham,%20England">West Stanley, Co Durham, England </PlaceOfBirth>
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  <DateOfDeath label="Date of death" urlencoded="18%2f04%2f2019" urlpathencoded="18/04/2019">18/04/2019</DateOfDeath>
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  <Activity label="Activity" urlencoded="Richard+Chambers+studied+the+synthesis+and+chemistry+of+organofluorine+compounds.+When+carbon%e2%80%93hydrogen+bonds+in+organic+compounds+replace+much+stronger+carbon%e2%80%93fluorine+bonds%2c+either+singly+or+multiply%2c+a+vast+range+of+%e2%80%98manmade%e2%80%99+molecules+becomes+available.+An+illustration+of+this+is+the+contrast+between+polypropene+and+inert+Teflon%2c+which+is+composed+of+all+carbon%e2%80%93fluorine+bonds.+Indeed%2c+fluorine-containing+compounds+have+wide-ranging+applications+in+industry%2c+including+unique+surface+effects+and+important+pharmaceuticals+such+as+anaesthetics.%0a%0aRichard+also+developed+methods+for+the+synthesis+many+new+compounds+that+are+useful+in+plant-protection+products%2c+inert+fluids+and+pharmaceuticals.+In+the+latter+case%2c+one+of+the+roles+of+fluorine+is+to+enhance+the+lifetime+of+a+drug+in+the+body.%0a%0aThe+chemistry+of+organofluorine+compounds+is+very+different+from+that+of+their+hydrocarbon+based+counterparts+and+therefore+poses+a+major+test+of+current+theories+of+mechanism+in+organic+chemistry.+Elemental+fluorine+is+the+most+reactive+of+the+elements%3b+the+design+and+use+of+microreactors+has+contributed+to+good+progress+in+the+synthesis+of+fluorine-containing+compounds+as+drug+candidates." urlpathencoded="Richard%20Chambers%20studied%20the%20synthesis%20and%20chemistry%20of%20organofluorine%20compounds.%20When%20carbon%e2%80%93hydrogen%20bonds%20in%20organic%20compounds%20replace%20much%20stronger%20carbon%e2%80%93fluorine%20bonds,%20either%20singly%20or%20multiply,%20a%20vast%20range%20of%20%e2%80%98manmade%e2%80%99%20molecules%20becomes%20available.%20An%20illustration%20of%20this%20is%20the%20contrast%20between%20polypropene%20and%20inert%20Teflon,%20which%20is%20composed%20of%20all%20carbon%e2%80%93fluorine%20bonds.%20Indeed,%20fluorine-containing%20compounds%20have%20wide-ranging%20applications%20in%20industry,%20including%20unique%20surface%20effects%20and%20important%20pharmaceuticals%20such%20as%20anaesthetics.%0a%0aRichard%20also%20developed%20methods%20for%20the%20synthesis%20many%20new%20compounds%20that%20are%20useful%20in%20plant-protection%20products,%20inert%20fluids%20and%20pharmaceuticals.%20In%20the%20latter%20case,%20one%20of%20the%20roles%20of%20fluorine%20is%20to%20enhance%20the%20lifetime%20of%20a%20drug%20in%20the%20body.%0a%0aThe%20chemistry%20of%20organofluorine%20compounds%20is%20very%20different%20from%20that%20of%20their%20hydrocarbon%20based%20counterparts%20and%20therefore%20poses%20a%20major%20test%20of%20current%20theories%20of%20mechanism%20in%20organic%20chemistry.%20Elemental%20fluorine%20is%20the%20most%20reactive%20of%20the%20elements;%20the%20design%20and%20use%20of%20microreactors%20has%20contributed%20to%20good%20progress%20in%20the%20synthesis%20of%20fluorine-containing%20compounds%20as%20drug%20candidates.">Richard Chambers studied the synthesis and chemistry of organofluorine compounds. When carbon–hydrogen bonds in organic compounds replace much stronger carbon–fluorine bonds, either singly or multiply, a vast range of ‘manmade’ molecules becomes available. An illustration of this is the contrast between polypropene and inert Teflon, which is composed of all carbon–fluorine bonds. Indeed, fluorine-containing compounds have wide-ranging applications in industry, including unique surface effects and important pharmaceuticals such as anaesthetics.

Richard also developed methods for the synthesis many new compounds that are useful in plant-protection products, inert fluids and pharmaceuticals. In the latter case, one of the roles of fluorine is to enhance the lifetime of a drug in the body.

The chemistry of organofluorine compounds is very different from that of their hydrocarbon based counterparts and therefore poses a major test of current theories of mechanism in organic chemistry. Elemental fluorine is the most reactive of the elements; the design and use of microreactors has contributed to good progress in the synthesis of fluorine-containing compounds as drug candidates.</Activity>
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  <Conventions label="Conventions" urlencoded="International+Standard+Archival+Authority+Record+for+Corporate+Bodies%2c+Persons+and+Families+-+ISAAR(CPF)+-+Ottawa+1996+ISBN+0-9696035-3-3%0a%0aNational+Council+on+Archives%2c+Rules+for+the+Construction+of+Personal%2c+Place+and+Corporate+Names%2c+1997" urlpathencoded="International%20Standard%20Archival%20Authority%20Record%20for%20Corporate%20Bodies,%20Persons%20and%20Families%20-%20ISAAR(CPF)%20-%20Ottawa%201996%20ISBN%200-9696035-3-3%0a%0aNational%20Council%20on%20Archives,%20Rules%20for%20the%20Construction%20of%20Personal,%20Place%20and%20Corporate%20Names,%201997">International Standard Archival Authority Record for Corporate Bodies, Persons and Families - ISAAR(CPF) - Ottawa 1996 ISBN 0-9696035-3-3

National Council on Archives, Rules for the Construction of Personal, Place and Corporate Names, 1997</Conventions>
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  <Created label="Created" urlencoded="21%2f11%2f2001" urlpathencoded="21/11/2001">21/11/2001</Created>
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pmab</Creator>
  <Modified label="Modified" urlencoded="28%2f03%2f2023" urlpathencoded="28/03/2023">28/03/2023</Modified>
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