Person Reich; Edward (1927 - 2018) Reich Edward 1927 - 2018 Canadian Male 03/04/1927 19270403 26/09/2018 20180926

Biochemist Edward Reich was known for his work on antibiotics that interact with nucleic acids and their related enzyme systems. He established that mitomycin C leads to loss of cellular nucleic acid and showed that actinomycines inhibit DNA-directed RNA synthesis, with selective interaction with deoxyguanosine residues and proposed a selective binding onto the exterior of helical DNA. He also established the properties of nucleotide analogues such as tubercidin and formycin. Edward developed the observation that tumour cells release fibrinolytic activity with a thorough study of both the release of plasminogen activators from cells and the relationship of this fibrinolytic activity to such fundamental matters as cell migration and inflammation, neoplasia, viral cell transformation, the release of the ovum at ovulation, trophoblast implantation and embryonic modelling. He purified nicotinic receptors and carried out extensive studies of the binding of drugs to them. Fellow 19/03/1981 53 International Standard Archival Authority Record for Corporate Bodies, Persons and Families - ISAAR(CPF) - Ottawa 1996 ISBN 0-9696035-3-3 National Council on Archives, Rules for the Construction of Personal, Place and Corporate Names, 1997 3 Apr 1927 - 26 Sep 2018 NA3964 21/11/2001 Andyg Pmab 28/03/2023 RS_NET\JonathanB Yes http://viaf.org/viaf/40876682 6ee674c6-fb63-4630-abf8-22ba5987cd1e