Person Iversen; Leslie Lars (1937 - 2020) Iversen Leslie Lars 1937 - 2020 British Male Exeter, Devon, England, United Kingdom 31/10/1937 19371031 30/07/2020 20200730

Pharmacologist Neuroscience Neurotransmitters Education: University of Cambridge, BA in Biochemistry (1961), PhD in Pharmacology (1964) Career: Director of the Medical Research Council Neurochemical Pharmacology Unit, Cambridge (1971-1982); Director of the Merck, Sharp & Dohme Neuroscience Research Centre (1982-1995); Visiting Professor of Pharmacology, Department of Pharamacology, University of Oxford (1995-2020); Director of the Wolfson Centre for Age-Related Diseases at King's College London (1999-2004); Chair of the Advisory Council on the Misuse of Drugs (2010-) Honours: CBE Memberships: American Academy of Arts and Sciences; Academia Europaea Married Susan Iversen FMedSci (1961) Through his contributions to the neurochemistry of synaptic transmitters, Leslie Iversen placed the study of uptake processes for noradrenaline on a quantitative basis and discovered a second non-neuronal uptake which leads to a rapid metabolic degradation of the accumulated amines. He exploited uptake processes in the study of the turnover of catecholamines and other synaptic transmitters and as a basis of an electron microscopic radioautographic method for delineating the transmitter specificity of terminal boutons. By this means, it was shown that gamma-aminobutyric acid (GABA) was taken up by a clearly defined subpopulation of nerve terminals distributed throughout the central nervous system. A selective loss of GABA-containing cells has been found in the basal ganglia of patients with Huntingdon’s chorea. Leslie (with Ed Kravitz, Masanori Otsuka and Zach Hall) was the first to demonstrate that GABA was released from inhibitory nerve terminals. He demonstrated trans-synaptic regulation of enzymes concerned with transmitter biosynthesis and has carried out extensive studies of the effect of nerve growth factor on the biochemistry of sympathetic neurons. Professor Leslie Iversen CBE FRS died on 30 July 2020. Royal Society roles: Council: 1990-1991 Committee and panels: Sectional Committee 8 (2004-2007); Sectional Committee 10 (2010-2013); Research Appointment Panel B (1999-2007) Lectures: Ferrier 1983 Fellow 20/03/1980 42 Sources: https://royalsociety.org/people/leslie-iversen-11687/; Wikipedia; Department of Phrmacology, University of Oxford https, ://www.pharm.ox.ac.uk/team/leslie-l-iversen (accessed 6 August 2020) International Standard Archival Authority Record for Corporate Bodies, Persons and Families - ISAAR(CPF) - Ottawa 1996 ISBN 0-9696035-3-3 National Council on Archives, Rules for the Construction of Personal, Place and Corporate Names, 1997 31 Oct 1937 - 20 Jul 2020 NA4454 21/11/2001 Andyg Pmab 23/03/2026 RS_NET\VirginiaM Yes http://viaf.org/viaf/18297678 5c978ceb-7c7c-498f-a121-212d271a19a4