Person Yanofsky; Charles (1925 - 2018) Yanofsky Charles 1925 - 2018 American Male New York, New York, USA 17/04/1925 19250417 16/03/2018 20180316

Geneticist Genetics Charles Yanofsky was a geneticist and molecular biologist. His research focused on the control of gene expression, and he specifically investigated how protein manufacture at the cellular level — a process known as transcription — is controlled in bacteria. He established the ‘one gene–one protein’ principle, which describes the linear relationship between a gene and the specific protein that it encodes. Through his research, Charles showed that the sequence of nitrogen bases in DNA relates exactly to the sequence of amino acids in the protein that the gene codes for. He found that changing the sequence of bases resulted in a corresponding change in the amino acid sequence. Charles went on to investigate the control of production of the amino acid tryptophan in Escherichia coli bacteria. He found that the bacterial cells could sense how much tryptophan was already present and reduce or stop transcription as necessary. For this important research, Charles won a number of awards, including the prestigious US National Medal of Science in 2003. Professor Charles Yanofsky ForMemRS died on 16 March 2018. Foreign Member 27/06/1985 60 References: R Holliday, 'The early years of molecular biology: personal recollections' in NR 2003 vol 57 pp 195-208 International Standard Archival Authority Record for Corporate Bodies, Persons and Families - ISAAR(CPF) - Ottawa 1996 ISBN 0-9696035-3-3 National Council on Archives, Rules for the Construction of Personal, Place and Corporate Names, 1997 17 Apr 1925 - 16 Mar 2018 NA4754 21/11/2001 Andyg Martind 28/03/2023 RS_NET\JonathanB Yes http://viaf.org/viaf/14252049 75595fa7-d6fb-45a9-809f-7b7e88ebb6e5