Person Sambrook; Joseph Frank (1939 - 2019) Sambrook Joseph Frank 1939 - 2019 British Male Liverpool, Merseyside, England, United Kingdom 01/03/1939 19390301 14/06/2019 20190614

Molecular biologist Biochemical genetics Molecular virology Cancer cells Education: University of Liverpool BSc hons (1962); Australian National University, PhD (1966) Career: Postdoctoral researcher, Medical Research Council Laboratory of Molecular Biology (1966 -1967), postdoctoral researcher Salk Institute for Biological Studies (1967-1969) ; Cold Spring Harbor Laboratory (1969); University of Texas Southwestern Medical Centre Dallas; Peter MacCallum Cancer Centre (1995); Executive Scientific Director of the Stem Cell Centre Monash University; founding Director of kConFaB, Australia's National Consortium for Research into Familial Breast Cancer Memberships: FAA Hired to work at Cold Spring Harbor Laboratory by James Watson FRS Joseph Sambrook made many important contributions to molecular and biochemical genetics, studying animal viruses, and particularly those viruses with DNA that integrate into the host cell genome. He was a member of the group that first demonstrated the physical integration of the DNA sequences of SV40 and other polyoma viruses into the chromosomes of the cells they transform. He subsequently defined the sequences which are necessary and sufficient to effect malignant transformation, and was a pioneer in the use of restriction enzymes for the physical mapping of mutations in adenovirus. He was the first to analyse the DNA sequences of the integration sites of SV40, work that confirmed the ‘onion skin’ model of excision. Joseph also analysed the expression of influenza virus haemagglutinin from genes cloned in SV40 vectors and studied the factors influencing the transport of haemagglutinin to the cell surface by in vitro modification of the genes. Fellow 21/03/1985 46 Sources: https://web.archive.org/web/20120317114007/http://www.thankyouday.org/ThankYouDayAwards/ThankYouDayAwards2009.aspx Reference: https://en.wikipedia.org/wiki/Joseph_Sambrook International Standard Archival Authority Record for Corporate Bodies, Persons and Families - ISAAR(CPF) - Ottawa 1996 ISBN 0-9696035-3-3 National Council on Archives, Rules for the Construction of Personal, Place and Corporate Names, 1997 1 Mar 1939 - 14 June 2019 NA4781 21/11/2001 Andyg Pmab 28/03/2023 RS_NET\JonathanB yes http://viaf.org/viaf/41900839 e273daa6-8556-4184-9703-d16e6f006f63