Person MacLennan; David Herman (1937 - 2020) MacLennan David Herman 1937 - 2020 Canadian Male Swan River, Manitoba, Canada, North and Central America 03/07/1937 19370703 24/06/2020 20200624

Biochemist Genetics Medical research Proteins Education: University of Manitoba, BSA (1959), DSc (2001); Purdue University, MS (1961), PhD (1963), Career: University of Wisconsin, Postdoctoral Fellow (1963-1964), Assistant Professor (1964-1968); Banting and Best Department of Medical Research, University of Toronto, Associate Professor (1969), Professor (1974), Chair (1978-1990), J. W. Billes Professor of Medical Research (1987-2007), University Professor (1993-2015) Honours: Officer of the Order of Canada 2001; Member of the Order of Ontario 2009 Memberships: Royal Society of Canada (1985); US National Academy of Sciences (2001); International Society for Heart Research (2001); Japanese Biochemical Society (2004); American Academy of Arts and Sciences (2015) Medals/Awards: Ayerst Award of the Canadian Biochemical Society 1974; National Lecturer Award of the Biophysical Society 1990; Gairdner Foundation International Award 1991; Killam Prize (Health Sciences) of the Canada Council for the Arts 1997; Canadian Medical Hall of Fame 2013 David MacLennan is a biochemist best known for his work on the proteins that regulate the flow, or flux, of calcium through the sarcoplasmic reticulum — thereby regulating muscle contraction and relaxation. His findings have led to important discoveries in the field of muscle diseases caused by genetic defects in calcium regulatory proteins. He developed a structural model for the relevant calcium pump based upon its amino acid sequence and the properties of over 250 altered pumps created using the technique of site-directed mutagenesis. Studies of these mutants led to new insight into the pump’s mechanism and provided an improved understanding of the genetic basis for human skeletal muscle conditions such as Brody myopathy and malignant hyperthermia. David has been elected as a Fellow of a number of prestigious international societies and received many awards, including the Canada Gairdner International Award in 1991 and the Killam Prize of the Canada Council for the Arts in 1997. He became an Officer of the Order of Canada in 2001. Professor David MacLennan OC FRS died on 24 June 2020. Medals and prizes: Glaxo Wellcome 2000 Lectures: Glaxo Wellcome 2000 Fellow 10/03/1994 56 Sources: https://royalsociety.org/people/david-maclennan-11861/ (accessed 22 July 2020); Wikipedia International Standard Archival Authority Record for Corporate Bodies, Persons and Families - ISAAR(CPF) - Ottawa 1996 ISBN 0-9696035-3-3 National Council on Archives, Rules for the Construction of Personal, Place and Corporate Names, 1997 3 Jul 1937 - 24 Jun 2020 NA7892 21/11/2001 Andyg Pmab 19/11/2025 RS_NET\VirginiaM Yes b724308e-c369-49f5-86c8-a2b1309c60a6