Person Ish-Horowicz; David (1948 - 2024); molecular biologist Horowicz David Ish- molecular biologist David Ish-Horowicz 1948 - 2024 British Male Manchester, England 02/08/1948 19480802 Oxford, England 19/07/2024 20240719

Molecular biologist Genetics Molecular biology Developmental genetics Cell biology Developmental biology Education: Manchester Grammar School; University of Cambridge Pembroke College BA 1966-1969; MRC Laboratory of Molecular Biology, Cambridge PhD 1969-1973 Career: Postdoctoral Fellow (Gehring Laboratory), Universität Basel Department Biozentrum (1973-1977); Head ICRF Developmental Genetics Laboratory (Mill Hill Laboratories), Cancer Research UK (1977-1985); Head, Developmental Genetics Laboratory (ICRF Developmental Biology Unit), Oxford (1985-1995); Head, ICRF/CR-UK Developmental Biology Unit (Developmental Biology Unit), London (1995-2013); Professor, Laboratory for Molecular Cell Biology, University College London (UCL) (2014-2024); died following his diagnosis with glioblastoma. Awards/Medals: Gulbenkian Science Prize 1997 Waddington Medal of the British Society of Developmental Biology 2007 Memberships: European Molecular Biology Organization Parents: Moshe Ish-Horowicz (1916–2008), prominent Reform Judaism leader in Manchester David Ish-Horowicz's research investigated the molecular and genetic mechanisms that establish, maintain and elaborate spatial organisation in vivo, in particular in Drosophila and vertebrate embryos. These studies led to major advances in our understanding of many distinct and conserved molecular processes that are used to pattern developing animals. Identified the first metazoan corepressor, Groucho, which - in conjunction with a wide variety of transcriptional repressors - prevents inappropriate transcription in many tissue contexts. He also showed how asymmetric protein production within the cell is achieved by transport of selected mRNAs along microtubules to specific cytoplasmic subregions. demonstrated that Notch intercellular signalling acts in vertebrate embryos to maintain a population of neuronal stem cells, and how the pathway also underlies the cyclic gene transcription which controls the regular production of reiterated body segments in vertebrate embryos. Commitees and Panels: Biological Sciences Awards Committee 2022-2024 Research Grants Committee: Biological Science 2018 Sectional Committee 7: Cell Biology 2015-2018 Royal Society Leverhulme Trust Sr. R'search F'ship Panel 2014-2016 International Exchanges Committee 2012-2017 Education Committee 2003-2007 Royal Society Research Grants Scheme - Board E 2003-2005 Fellow 13/05/2002 54 The Royal Society Fellows Directory, Professor David Ish-Horowicz FRS, [URL: https://royalsociety.org/people/david-ish-horowicz-11683/; last accessed: 19/02/2025] Current Biology, Volume 34, Issue 20, October 21, 2024, Philip W. Ingham, Obituary David Ish-Horowicz (1948–2024) [URL: https://www.cell.com/current-biology/fulltext/S0960-9822(24)01212-0] International Standard Archival Authority Record for Corporate Bodies, Persons and Families - ISAAR(CPF) - Ottawa 1996 ISBN 0-9696035-3-3 National Council on Archives, Rules for the Construction of Personal, Place and Corporate Names, 1997 Anglo American Cataloguing Rules (second edition) rules for double barrelled and compound surnames https://royalsocietypublishing.org/action/doSearch?ContribAuthorRaw=Ish-Horowicz+FRS%2C+David+FRS RCN R69808 The past Fellows entries are under continuous revision. If you have queries or additional information to contribute, please contact Library@royalsociety.org. Content in external sources is not controlled by the Royal Society and historical sources may include content that is now unacceptable. Reviewed on 19/02/2025 as part of the Name Authority Project update. NA8468 10/05/2002 Clara 27/08/2025 RS_NET\VirginiaM Yes 8242de93-ad77-4743-b127-db5a5ca54f1d