Person Jackson; Richard James (1940 - 2020) Jackson Richard James 1940 - 2020 British Male Bournemouth, Bournemouth, England, United Kingdom 01/07/1940 19400701 21/09/2020 20200921

Biochemist Biology Cell biology Proteins Ribosomes Messenger RNA Education: University of Cambridge, PhD Career: Professor of RNA (later Emeritus), Department of Biochemistry, University of Cambridge Memberships: European Molecular Biology Organisation Richard Jackson made major contributions to cell biology, focusing on the moment at which ribosomes within the cell begin to translate the cell’s genetic instructions, in the form of messenger RNA (mRNA), into protein products. Understanding how the cell regulates this translation process has significant implications for new therapies in cancer and a range of viral diseases. Eleven different eukaryotic initiation factors, or eIFs, participate in regulating translation, and Richard developed standard methods of studying their interactions in cultured cells. He explored how these factors enable the ribosome to select the correct initiating site by scanning from one end of an mRNA molecule. He also investigated ‘internal ribosome entry segments’ (IRESs) in both cellular and viral mRNA where ribosomes initiate translation directly. Richard continued to study the way IRESs enable viruses to subvert the host’s protein production machinery. Professor Richard Jackson FRS died on 21 September 2020. Fellow 18/05/2006 65 Sources: https://royalsociety.org/people/richard-jackson-11688/ (accessed 29 September 2020) International Standard Archival Authority Record for Corporate Bodies, Persons and Families - ISAAR(CPF) - Ottawa 1996 ISBN 0-9696035-3-3 National Council on Archives, Rules for the Construction of Personal, Place and Corporate Names, 1997 Jackson RJ (2013). The current status of vertebrate cellular mRNA IRESs. Cold Spring Harb. Perspect. Biol., 5(2):a011569. doi: 10.1101/cshperspect.a011569 Pöyry TA, Kaminski A, Connell EJ, Fraser CS, Jackson RJ (2007). The mechanism of an exceptional case of reinitiation after translation of a long ORF reveals why such events do not generally occur in mammalian mRNA translation. Genes Dev., 21(23):3149-3162. doi: 10.1101/gad.439507 Kafasla P, Morgner N, Pöyry TA, Curry S, Robinson CV, Jackson RJ (2009). Polypyrimidine tract binding protein stabilizes the encephalomyocarditis virus IRES structure via binding multiple sites in a unique orientation. Mol. Cell, 34(5):556-568. doi: 10.1016/j.molcel.2009.04.015 Kafasla P, Morgner N, Robinson CV, Jackson RJ (2010). Polypyrimidine tract-binding protein stimulates the poliovirus IRES by modulating eIF4G binding. EMBO J., 29(21):3710-3722. doi: 10.1038/emboj.2010.231 Pöyry TA, Jackson RJ (2011). Mechanisms governing the selection of translation initiation sites on foot-and-mouth disease virus RNA. J. Virol., 85(19):10178-10188. doi: 10.1128/JVI.05085-11 1 July 1940 - 21 Sep 2020 NA9218 24/05/2006 Joanna 28/03/2023 RS_NET\JonathanB Yes 4ca9f1a5-30a8-44a5-8f87-d49625bf49c1