| Citation | Distinguished for his contributions to the understanding of the neural basis of learning and memory in the mammalian brain and in particular for his discovery, with Terje Lomo, of the phenomenon of long-term potentiation and his futther elucidation of its cellular basis. It has for long been presumed that information is stored in the brain as activity-induced changes in the efficacy of synaptic connections, but synapses possessing this property were unknown until their identification in the hippocampus by Bliss and Lomo. Bliss has gone on to demonstrate that a sustained increase in transmitter release contributes to the changed efficacy and has provided evidence for his influential suggestion that a retrograde synaptic messenger plays an obligatory role in the induction of long-term potentiation. His discoveries have had a major influence in neurophysiology, neuropsychology and computational neurobiology. |