| Citation | Richard Moxon is distinguished for his work in bacterial genetics, the identity of vaccine candidates, and for pioneering important vaccine programmes. The first to develop a rodent model of bacterial meningitis, he carried out seminal studies on the biosynthesis, transport and assembly of the type b capsule antigen of H. influenzae, established it as a vaccine candidate, introduced type b conjugate vaccine into the UK and organised safety and pilot trials leading to a successful vaccine programme. Recently he has investigated adaptive mechanisms in bacterial pathogens, demonstrating the role of variation in repeat sequences, and has identified new families of virulence genes from the genome of H. influenzae. |