| Citation | Ritchie's early work was concerned with the factors affecting the onset and duration of the active state in striated muscle, and with other aspects of the dynamics of muscular contraction. In 1954 he turned his attention to the properties of mammalian non-myelinated nerve fibres, and since then has made many distinguished contributions to our knowledge not only of some of the physiological functions served by such fibres, but also of the mechanism of conduction in them. In particular, he has been responsible for definitive studies of the mode of action of acetylcholine and local anaesthetics, of the ionic movements during nervous activity, of the temperature changes during the nervous impulse, of oxidative and glucose metabolism, and of the electrogenic sodium extrusion that underlies post-tetanic hyperpolarization. His most recent work on the specific and non-specific binding of tetrodotoxin has provided new information about the density of sodium channels in various types of nerve. |