| RefNo | EC/1983/22 |
| Previous numbers | Cert XXI, 110 |
| Level | Item |
| Title | Marsden, Charles David: certificate of election to the Royal Society |
| Date | 1982 |
| Description | Citation typed |
| Citation | Marsden can be counted one of the leading neurological scientists of his generation. As a clinician, he is a world authority on diseases characterised by disorders of movement, such as Parkinson's disease, and has described some half dozen new syndromes. Numerous other clinical papers cover a wide field. His parallel success in the experimental pharmacology of movement disorder stems from his rare ability to combine animal and in vitro experiments with clinical testing of new remedies. Marsden has achieved significant therapeutic advances in e.g. essential tremor, action myoclonus and chorea. At the same time he has thrown new light on the mode of action of anti-Parkinsonian drugs, and on the role of dopamine in the normal functions of the extrapyramidal system. The demonstration that adaptive changes occur in brain dopamine mechanisms after long term dosage of animals with drugs used clinically to treat schizophrenia is a particularly important advance, bearing on the dopamine hypothesis of schizophrenia. In physiological circles Marsden is known for his elegant demonstration (1967) that adrenaline causes tremor by a peripheral action on muscle, and for his part in the work that demonstrated servo control of voluntary movement in man and revealed the related postural mechanisms. These investigations were begun in collaboration with Merton and Morton, but now continue independently in Marsden's laboratory too, where recently the postural abnormalities in Parkinson's disease have been analysed. |
| AccessStatus | Closed |
Fellows associated with this archive
| Code | PersonName | Dates |
| NA222 | Marsden; Charles David (1938 - 1998) | 1938 - 1998 |