| Citation | Krishna Chatterjee is distinguished for his contribution to the molecular basis of endocrine disorders and its application to clinical medicine. His discoveries of genetic disorders of thyroid gland formation, regulation of hormone synthesis and hormone action, have advanced fundamental knowledge of the thyroid axis. He has identified dominant negative inhibition by defective nuclear hormone receptors as a common mechanism in Resistance to Thyroid Hormone beta or alpha and PPARgamma-mediated insulin resistance. Such understanding has informed nuclear receptor drug development and altered therapeutic approach in these disorders. |