| RefNo | EC/2020/19 |
| Level | Item |
| Title | Jackson, Andrew: certificate of election to the Royal Society |
| Date | 14 April 2020 |
| Description | Certificate endorsing election of Andrew Jackson as a Fellow of the Royal Society. Includes personal details of the elected Fellow, citaion giving the reasons for election, and names of proposers. Signed by the Executive Director of the Royal Society, Julie Maxton. |
| Citation | Andrew Jackson has made important contributions to two major scientific areas, linking human genetics to genome stability in both. He has identified many genes that are crucial for the normal development and growth of the human brain. His analysis of these gene products has defined their fundamental roles genome in replication, DNA damage response and in mitosis. His most significant achievement concerns the nuclease, Ribonuclease H2. Through identification of three genes causing a congenital neuroinflammatory disorder, Aicardi-Goutieres syndrome, he reconstituted the encoded human ribonuclease heterotrimeric protein complex and minimally reconstituted its biochemical activity. Extending further on this work, Jackson demonstrated that Ribonuclease H2 is a developmentally essential mammalian genome repair enzyme because it facilitates the removal of ribonucleotides that are embedded in the genome. In fact such embedded ribonucleotides are ubiquitous and without their excision they would pose an enormous source of endogenous DNA damage, perhaps greatly exceeding that repaired by most known DNA repair pathways. |
| Extent | 4p |
| Format | Computer printout |
| PhysicalDescription | A4 papers |
| AccessStatus | Closed |
| AccessConditions | Election certificates are subject to 50 year closure period from date of election. Details of proposers are kept confidential until the 50 year closure period has elapsed. |