| RefNo | EC/2024/38 |
| Level | Item |
| Title | Komander, David: certificate of election to the Royal Society |
| Date | 21 April 2024 |
| Description | Certificate endorsing election of David Komander as a Fellow of the Royal Society. Includes personal details of the elected Fellow, citation giving the reasons for election, and names of proposers. Signed by the Executive Director of the Royal Society, Julie Maxton. |
| Citation | David Komander has discovered proteins that assemble, recognize and remove specific ubiquitin signals, unveiling the remarkable complexity of the ‘Ubiquitin Code’ beyond protein degradation, and how its deregulation drives human disease. He discovered OTULIN, a missing piece in linear ubiquitination, and showed that its loss causes a potentially fatal autoimmune syndrome. He provided a complete molecular picture of mitophagy regulators PINK1, Parkin and USP30, and deep understanding of ubiquitin signalling in Parkinson’s disease. His work has illuminated the importance of ubiquitin in modulating cell function and has laid the foundation to understand, and eventually treat, cancer, inflammatory and neurodegenerative diseases. |
| Extent | 4p |
| Format | Computer printout |
| PhysicalDescription | A4 papers |
| AccessStatus | Closed |
| AccessConditions | Election certificates are subject to 50 year closure period from date of election. Details of proposers and date certificate was first submitted for candidacy are kept confidential until the 50 year closure period has elapsed. |