| RefNo | EC/2024/62 |
| Level | Item |
| Title | Shi, Yang: certificate of election to the Royal Society |
| Date | 21 April 2024 |
| Description | Certificate endorsing election of Yang Shi as a Fellow of the Royal Society. Includes personal details of the elected Fellow, citation giving the reasons for election, and names of proposers. Signed by the Executive Director of the Royal Society, Julie Maxton. |
| Citation | Shi’s landmark discovery of the first histone demethylase, LSD1, overturned the long-held dogma that histone methylation was irreversible and set the standard for an avalanche of additional demethylase discoveries for which Shi was a major contributor. Shi and collaborators provided the first atomic level insight into mechanism of demethylation and transcriptional regulation. Shi discovered the link between histone methylation dynamics and intellectual disability and developed strategies, now in clinical trials, to enable immune checkpoint blockade by modulating LSD1. Shi’s extraordinary record of pioneering/paradigm-shifting discoveries have revolutionized the fields of chromatin and epigenetics and have far-reaching impacts in biology and medicine. |
| Extent | 4p |
| Format | Computer printout |
| PhysicalDescription | A4 papers |
| AccessStatus | Closed |
| AccessConditions | Election certificates are subject to 50 year closure period from date of election. Details of proposers and date certificate was first submitted for candidacy are kept confidential until the 50 year closure period has elapsed. |