| RefNo | EC/2024/67 |
| Level | Item |
| Title | Vanhaesebroeck, Bart: certificate of election to the Royal Society |
| Date | 21 April 2024 |
| Description | Certificate endorsing election of Bart Vanhaesebroeck as a Fellow of the Royal Society. Includes personal details of the elected Fellow, citation giving the reasons for election, and names of proposers. Signed by the Executive Director of the Royal Society, Julie Maxton. |
| Citation | BV has made fundamental discoveries about how lipid second messengers are regulated to control cellular and organismal functions. His contributions include showing non-redundant functions of different phosphoinositide-3- kinase (PI3K) isoforms. Notably, he identified and characterised PI3K-p110 which is expressed selectively in leukocytes and some cancer cells. It is now known that mutants of this enzyme cause human immunodeficiency and autoimmunity. He has driven the generation of isoform-selective PI3K-inhibitors that are used clinically as immune therapeutics and for cancer treatment. His recent development of small-molecule PI3K activators has turned decades of PI3K research on its head, opening new avenues for kinase drug development. |
| Extent | 4p |
| Format | Computer printout |
| PhysicalDescription | A4 papers |
| AccessStatus | Closed |
| AccessConditions | Election certificates are subject to 50 year closure period from date of election. Details of proposers and date certificate was first submitted for candidacy are kept confidential until the 50 year closure period has elapsed. |