| Citation | Distinguished for his studies of the mechanism of active transport of ions in animal tissues. Demonstrated the special asymmetry of the ATPase of red cell membrane which acts only wgen Na+ is inside and K+ outside the membrane. Was the first to demonstrate that active transport can exert a feed-back control over the rate of cellular metabolism. These concepts, of directionality as an inherent part of an enzyme reaction in membranes and of the fundamental significance for the understanding of the relations between physiological function and the mechanism of enzyme action. |