| RefNo | EC/1980/14 |
| Previous numbers | Cert XX, 191 |
| Level | Item |
| Title | Iversen, Leslie Lars: certificate of election to the Royal Society |
| Date | 1975 |
| Description | Citation typed |
| Citation | Distinguished for his contribution to the neurochemistry of synaptic transmitters. Iversen has placed the study of uptake processes for noradrenaline on a quantitative basis and has discovered a second non-neuronal uptake which leads to a rapid metabolic degradation of the accumulated amines. He has exploited uptake processes in the study of the turnover of catechol amines and other synaptic transmitters and as a basis of an e.m. radioautographic method for delineating the transmitter specificity of terminal boutons. By this means it was shown that gamma aminobutyric acid (GABA) was taken up by a clearly defined subpopulation of nerve terminals distributed throughout the central nervous system. A selective loss of GABA containing cells has been found in the basal ganglia of patients with Huntingdon's chorea. Iversen (with Kravitz, Otsuka and Hall) was the first to demonstrate that GABA was released from inhibitory nerve terminals. He has demonstrated trans-synaptic regulation of enzymes concerned with transmitter biosynthesis and has carried out extensive studies of the effect of nerve growth factor on the biochemistry of sympathetic neurones. |
| AccessStatus | Closed |
Fellows associated with this archive
| Code | PersonName | Dates |
| NA4454 | Iversen; Leslie Lars (1937-2020) | 1937-2020 |