RefNo | EC/2019/53 |
Level | Item |
Title | Clevers, Hans: certificate of election to the Royal Society |
Date | 28 March 2019 |
Description | Certificate endorsing election of Hans Clevers as a Foreign Member of the Royal Society, including personal details of the elected Foreign Member and citing the reasons for election and names of proposers. Signed by the Executive Director of the Royal Society, Julie Maxton. |
Citation | Clevers uncovered how Wnt signals control gene expression during animal embryogenesis. Looking beyond embryogenesis, he unveiled the role of Wnt signaling in colon cancer and in its physiological counterpart, the selfrenewing gut epithelium. Combining these insights, he discovered the generic marker gene Lgr5, which identified stem cells in virtually all mammalian organs. He devised protocols to expand these stem cells indefinitely as organoids, thereby pioneering the use of mini-organs that recapitulate healthy or diseased human tissue in a dish. Organoids are now widely used in basic and applied biomedicine, occupying a niche between 'classical' 2D cell lines and experimental animals. |
Extent | 4p |
Format | Computer printout |
PhysicalDescription | A4 papers |
AccessStatus | Closed |
AccessConditions | Election certificates are subject to 50 year closure period from date of election. Details of proposers are kept confidential until the 50 year closure period has elapsed. |