| RefNo | EC/1974/20 |
| Previous numbers | Cert XIX, 131 |
| Level | Item |
| Title | Perry, Samuel Victor: certificate of election to the Royal Society |
| Description | Citation typed |
| Citation | Distinguished for his work on muscle proteins. For 25 years he has pioneered and consolidated advances over a remarkably wide front. First showed the importance of SH groups in the interaction of actin with myosin and has greatly clarified the activating effect of actin on myosin ATPase. First to isolate myosin subfragment 1. Discovered that the actin-myosin system alone, unlike the myofibril, lacks EDTA sensitivity and drew the correct inference that some other cation besides Mg is concerned. Later successfully studied the regulatory system involving Ca (the tropmyosin-toponin complex) identifying the several components and their functions, thereby elucidating the mechanism that controls contraction and relaxation. Showed 3-methyl histidine in myosin and actin (previously unknown in a protein) and studied the methylating enzyme. Has done much interesting work on the myofibrillar and sarcoplasmic proteins of developing and dystrotrophic muscles, and on effects of exercise on synthesis of certain enzymes concerned in contraction. His recent work includes the discovery that one of the myosin light chains can be phosphorylated. He has stimulated many collaborators. His work is characterised by wide biological interest and by exceptional experimental thoroughness and perceptiveness. |
| AccessStatus | Closed |
Fellows associated with this archive
| Code | PersonName | Dates |
| NA5263 | Perry; Samuel Victor (1918 - 2009) | 1918 - 2009 |