Citation | Distinguished for his studies of enzyme regulation and membrane fixed functions. In 1967 Radda introduced the use of fluorescent probes for the study of enzyme conformations in relation to regulation, and has studied in particular detail glutamate dehydrogenase and the phosphorylase system. A wide range of physical methods has been used as well as fluorescence, and in recent years Radda has exploited magnetic resonance methods and has used phosphorus resonances to study highly organised biological systems. In 1969 he was the first to use fluorescent probes to study the dynamic properties of biological membranes and has recently extended this to magnetic resonance measurements on real and model membranes. More recently he has developed new methods for the study of the membrane bound enzymes involved in the synthesis and hydrolysis of ATP in mitochondrial, bacterial and chromaffin granule membranes. |