RefNo | EC/1983/23 |
Previous numbers | Cert XXI, 111 |
Level | Item |
Title | Metcalf, Donald: certificate of election to the Royal Society |
Date | 1982 |
Description | Citation typed |
Citation | Distinguished for studies on the control of proliferation and differentiation in normal and leukaemic blood cells. His pioneer work demonstrated the regulatory control of the thymus on other lymphoid populations and the autonomous intrathymic control systems regulating lymphocyte formation. His development of a series of semi-solid cloning systems for various normal and leukaemic blood-forming precursors initiated a large new field of cell biology. He demonstrated the existence of a family of glycoprotein regulators (CSF's) each controlling the proliferation and differentiation of a specific haemopoietic family of cells. Two of these have been purified and their action characterized biochemically. He demonstrated that all myeloid leukaemias in man are CSF-dependent and that in murine models, myeloid leukaemia can be suppressed by using normal haemopoietic regulators to force terminal differentiation. |
AccessStatus | Closed |
Fellows associated with this archive
Code | PersonName | Dates |
NA1354 | Metcalf; Donald (1929 - 2015) | 1929 - 2015 |