| RefNo | EC/1996/15 |
| Level | Item |
| Title | Jessell, Thomas Michael: certificate of election to the Royal Society |
| Date | 1994 |
| Description | Citation typed |
| Citation | Distinguished for his work on the functional organisation and development of the spinal cord. He showed that fast neorotransmission at primary afferent synapses is mediated by excitatory amino acids and that the release of substance P from primary afferent nerve terminals is selectively suppressed by opioid peptides. He demonstrated that in the developing spinal cord the floor plate is induced by a contact-dependent signal from the notochord and the differentiation of motor neurons is induced by a diffusible factor from the notochord and floor plate. He identified transcription factors that contribute to the specification of the floor plate and motor neurons, and he has identified a novel growth factor that is required for the differentiation of dorsal cell types, including the neural crest. He has characterised a diffusible chemotropic factor secreted by floor plate cells that helps guide comissural axons across the ventral midline, and he has identified a novel cell-surface protein, TAG-1, that is expressed on commissural axons but is lost as they cross the midline. |
| AccessStatus | Closed |
Fellows associated with this archive
| Code | PersonName | Dates |
| NA4251 | Jessell; Thomas Michael (1951 - 2019) | 1951 - 2019 |