| RefNo | EC/1999/21 |
| Level | Item |
| Title | McCulloch, Ernest Armstrong: certificate of election to the Royal Society |
| Date | 1997 |
| Description | Citation typed |
| Citation | With his colleague Till, McCulloch founded the field of modern haematology by demonstrating the existence of haemopoietic stem cells that give rise to all blood cell types. They devised the first functional assay (the spleen colony assay) for blood cell precursors and used it to demonstrate that haemopoietic stem cells have the properties of self-renewal, proliferation and multilineage differentiation. Using irradiation-induced chromosome breaks to follow individual precursor cells and their progeny, they demonstrated that each spleen colony was a clone. Their contributions laid the foundation for the isolation of haemopoietic stem cells, for bone marrow transplantation and for the eventual search for haemopoietic cytokines. |
| AccessStatus | Closed |
Fellows associated with this archive
| Code | PersonName | Dates |
| NA2357 | McCulloch; Ernest Armstrong (1926 - 2011) | 1926 - 2011 |