| RefNo | EC/2018/04 |
| Level | Item |
| Title | Brimble, Margaret Anne: certificate of election to the Royal Society |
| Date | 9 May 2018 |
| Description | Certificate endorsing election of Margaret Brimble as a Fellow of the Royal Society, including personal details of the elected Fellow and citing the reasons for election and names of proposers. Signed by Executive Director of the Royal Society, Julie Maxton. |
| Citation | Margaret Brimble is distinguished for her impressive contributions to the synthesis of bioactive natural products and peptide mimics including the development of NNZ2566 (trofinetide) the first drug for Rett Syndrome and Fragile X Syndrome, also in phase 2 trials for Traumatic Brain Injury. She has developed elegant syntheses of polyether antibiotics, neuroactive shellfish toxins, anticancer and antiviral agents, natural products from extremophiles, antimicrobial (glyco)peptides and alkaloids. The targets were constructed using an extensive array of synthetic reactions including radical oxidative cyclization, silyloxyfuran annulation/oxidative rearrangement, double-Mannich reaction and solid phase glycation and lipidation to prepare biomolecule-conjugated peptides. |
| Extent | 4p |
| Format | Computer printout |
| PhysicalDescription | A4 papers |
| AccessStatus | Closed |
| AccessConditions | Election certificates are subject to 50 year closure period from date of election. Details of proposers are kept confidential until the 50 year closure period has elapsed. |