| RefNo | EC/2019/48 |
| Level | Item |
| Title | Tomlinson, Ian Philip Mark: certificate of election to the Royal Society |
| Date | 28 March 2019 |
| Description | Certificate endorsing election of Ian Tomlinson as a Fellow of the Royal Society, including personal details of the elected Fellow and citing the reasons for election and names of proposers. Signed by the Executive Director of the Royal Society, Julie Maxton. |
| Citation | Ian Tomlinson is a clinician scientist who has combined molecular genetic analysis of familial and sporadic cancer with population studies to identify new mechanisms of cancer growth and new theories of cancer evolution. He has discovered novel and unexpected oncogenic pathways including dysregulated bone morphogenetic protein signalling in colorectal cancer and defects in the Krebs cycle enzyme, fumarate hydratase in kidney cancer. Through precise analyses of the mutational spectrum in cancer and the functional consequences, his work has also changed general thinking towards a "just right" model in which tumourigenesis is driven by quantitative functional changes that are neither too weak nor too strong. |
| Extent | 4p |
| Format | Computer printout |
| PhysicalDescription | A4 papers |
| AccessStatus | Closed |
| AccessConditions | Election certificates are subject to 50 year closure period from date of election. Details of proposers are kept confidential until the 50 year closure period has elapsed. |