Citation | Discovered the transference of transplantation immunity by sensitised cells, so providing the key evidence relating transplantation immunity to hypersensitivity reaction of 'delayed' type. Devised a method for revealing mixtures of cells of different genotypes in vivo and used it to be equal first with demonstration that the 'radiation recovery factor' is a graft of living cells and not a humoral agent. Carried out the most exact quantitative analysis of tolerance hitherto attempted in a cellular system and proved inter alia that persistence of tolerance depends on persistence of antigen. Mitchison has thus made notable and distinctive contributions to immunology. |