| RefNo | EC/1968/01 |
| Previous numbers | Cert XVIII, 74 |
| Level | Item |
| Title | Anderson, Ephraim Saul: certificate of election to the Royal Society |
| Description | Citation typed |
| Citation | Anderson's most outstanding work was the clear demonstration that the Vi typing phages for Salmonella typhi, introduced by Craigie and Yen in 1938, acquire their type specificity by one or the other of two distinct mechanisms, either host-range mutation or phenotypic modification, and that the former kind of specificity is generally determined by a series of unrelated phages carried by the various types of bacterial host. By artificiality lysogenising phage-free bacteria with different type-determining phages, Anderson demonstrated that not only pre-existing types but also quite new types of Salm.typhi could be "synthesised" in the laboratory. In 1947 he discovered phenotypic modification in phage. Unfortunately his discovery was not published until 1952 by which time Luria and Human had discovered the phenomenon independently and had published their observations on phenotypic change in phage T2 earlier the same year. He has recently initiated research on the important problem of the inheritance of multiple drug resistance in salmonellas, where the genetic determinants of resistance to many antibiotics are carried by a single transmission sex factor. Among epidemiologists studying typhoid Anderson is quite outstanding. |
| AccessStatus | Open |
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Fellows associated with this archive
| Code | PersonName | Dates |
| NA3897 | Anderson; Ephraim Saul (1911 - 2006) | 1911 - 2006 |