| RefNo | EC/1976/17 |
| Previous numbers | Cert XX, 17 A02806 |
| Level | Item |
| Title | Goodwin, Leonard George: certificate of election to the Royal Society |
| Date | 1971 |
| Description | Citation handwritten. |
| Citation | Distinguished for his notable contributions to pharmacology and to the chemotherapy of parasitic infections, particularly those which cause 'tropical' diseases. He devised a method for making quantitative estimates of the porency of antimonial compounds in the treatment of experimental leishmaniasis in the hamster which enabled him to identify sodium stibogluconate (Pentostam) as the most efficient drug for the treatment of human leishmaniasis. Studies of over 300 diaminopyrimidines led him to select pyrimethamine (Daraprim) for the prophylaxis and treatment of human malaria. He made extensive investigations into the relationship of chemical structure and pharmacological activity in phenanthridine compounds used in the treatment of animal trypanosomiasis. He evolved an ingenious method of demonstrating the action of anthelminthics on round worms which was used in the study of piperazine compounds. By demonstrating the action of diphenxyalkanes in inhibiting the synthesis of visual purple in frog's eyes he showed that these drugs, proved to be highly efficient schistosomicides in infected mice, were unsuitable for use in man. In rabbits infected with Trypanosoma brucei he has recently discovered that heavy concentrations of the parasites occur in tissue spaces where they produce massive destruction of connective tissue with liberation into the circulation of peptides of the kinin type - an observation of much importance which opens up new lines of investigation. |
| AccessStatus | Closed |
Fellows associated with this archive
| Code | PersonName | Dates |
| NA4155 | Goodwin; Leonard George (1915 - 2008) | 1915 - 2008 |