| RefNo | EC/1988/34 |
| Previous numbers | Cert XXII, 131 |
| Level | Item |
| Title | Shooter, Eric Manvers: certificate of election to the Royal Society |
| Date | 1981 |
| Description | Citation typed. Letter regarding nationality attached |
| Citation | Distinguished for his studies of the chemistry and biochemistry of nerve growth factor (NGF). Showed that NGF consists of two peptide chains of identical sequence but unequal length, associated non covalently. Crystallised NGF and showed that activity is unaffected by removal of N terminal octapeptide or C-terminal arginine. In the cell is in the form of a 7S complex with a specific arginine endopeptidase and alpha-subunits which inhibit the peptidase and nerve growth activity; the 7S complex is secreted in the saliva. Demonstrated two classes of cellular receptor for NGF. The high affinity receptor is only present at the developmental age when the neurons are responsive. Discovered a haemoglobin variant with abnormal alpha and beta chains giving evidence of two synthetic genes. |
| Extent | 2 sheets |
| AccessStatus | Closed |
Fellows associated with this archive
| Code | PersonName | Dates |
| NA6182 | Shooter; Eric Manvers (1924 - 2018) | 1924 - 2018 |