| RefNo | EC/1992/12 |
| Level | Item |
| Title | Hales, Charles Nicholas: certificate of election to the Royal Society |
| Date | 1985 |
| Description | Citation typed |
| Citation | Distinguished for related work on immunological methods in endocrinology, on insulin secretion, and on cell metabolism. He originated and established the immunoradiometric assay for peptides; his published methods include several hormones and transferrin. There are important differences in principle between his assay and radioimmunoasssay and it has many advantages; for example it can be multisite, providing a means of distinguishing between prohormones, hormones and other conversion products sharing common amino acid sequences. The importance of his method has become widely recognised with the availability of monoclonal antibodies. His introduction of solid phase antibodies into radioimmunoassay led to the first kit and was of outstanding practical importance (more than 2000 citations, up to 1975). In studies of insulinaemia and response to hyperglycaemia he discovered modulation by diet and hyperphagia and evidence of alterations in people destined to become diabetic. By studies of insulin secretion in vitro, he showed the requirement for calcium and sodium, and stimulation by barium and potassium. He has applied electron microscopy and electron probe microanalysis to cation distribution in pancreatic B-cells. Other important contributions to cell metabolism include the discovery of lysosomal monosaccharide transport. |
| AccessStatus | Closed |
Fellows associated with this archive
| Code | PersonName | Dates |
| NA4209 | Hales; Charles Nicholas (1935 - 2005) | 1935 - 2005 |