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RefNoEC/1995/18
LevelItem
TitleMarshall, Christopher John: certificate of election to the Royal Society
Date1993
DescriptionCitation typed on separate piece of paper, then taped onto certificate
CitationSince 1981, C.J. Marshall's research has focussed on ras oncogenes and their role in cell transformation. He has made major contributions to the discovery of these genes and to the analysis of their oncogenic activity. In 1982, he discovered the N-ras oncogene (simultaneously with the Weinberg and Wigler groups). His subsequent work has been in three main areas. First, he showed that N-ras is the most frequently activated ras oncogene in human leukaemias, and is likely to promote growth of the most aggressive cell clones. Second, he demonstrated that mutant p21ras activates a protein kinase C dependent signal transduction pathway that is responsible for the induction of DNA synthesis. He demonstrated that oncogenic p21ras activates extracellular signal induced (MAP) kinases, and does so constitutively in ras-transformed cells and in human tumours containing ras oncogenes. Furthermore, he has discovered one of the critical components of the mitogenic signalling pathway by showing that raf protein kinase is the link between p21ras and activation of the MAP kinases. Third, he showed that the C-terminal CAAX encoding p21-ras proteins is a signal for farnesylation, and that this is required for membrane localization and transformation. This has led to the use of agents that block post-translational modification as inhibitors of cell transformation and potentially of tumours.
AccessStatusClosed
Fellows associated with this archive
CodePersonNameDates
NA4576Marshall; Christopher John (1949 - 2015)1949 - 2015
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