| Citation | Dr John D Scott has pioneered the analysis of anchoring and scaffolding proteins, that play a critical role in organizing the process of cellular signal transduction. His work has been instrumental in defining a family of A-kinase anchoring proteins, termed AKAPs, that function to target the cAMP-dependent protein kinase and other signalling enzymes to specific subcellular locations. An elegant combination of molecular and plhysiological approaches have been used to define the mechanisms by which AKAPs interact with their targets, and to identify cellular activities that depend on AKAP function, such as the modulation of various ion channels, insulin secretion from ßislet cells, cytoskeletal reorganization and specific transcription events. Dr Scott's work has markedly altered the way we think about signal transduction pathways. |