Citation | Matthew Freeman has studied the regulation of intercellular signalling, mainly in Drosophila. He showed, in the eye, that repeated signalling through the epidermal growth factor receptor (EGFR) is used to determine all retinal cell fates; this model has become a paradigm for induction by receptor tyrosine kinases. Dissecting and studying the molecular components of EGFR signalling, he showed how the receptor can establish pattern, for example through feedback regulation. His discoveries include the signalling inhibitors Argos and Sprouty, and he has shown that rhomboids are a novel family of intramembrane proteases that are conserved throughout evolution. |