Citation | Gill Bates has been sat at the forefront of Huntington's disease research for the past 15-20 years. She played a key role in the cloning of the Huntington's disease gene by conducting all of the long-range cloning and physical mapping that contributed to that endeavour. She generated the first mouse model of HD, which has been pivotal in uncovering previously unknown aspects of HD pathogenesis and identifying novel therapeutic targets. She was the first to show that histone deacetylase inhibitors show efficacy in preclinical mouse trials for HD; this class of drugs is currently entering into phase II clinical trials. In recognition of her significant contributions to the understanding of Huntington's Disease, she was awarded the Royal Society Glaxo Wellcome Award in 1998 (with Stephen Davies). |