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RefNoEC/2007/19
LevelItem
TitleHardie, David Grahame: certificate of election to the Royal Society
DescriptionCertificate of Election
CitationGrahame Hardie identified the AMP-activated protein kinase (AMPK), its regulation by 5'AMP and phosphorylation and several physiological roles. He introduced the concept that AMPK is a sensor of cellular energy charge and showed that it stimulates glucose uptake into muscle during exercise. This led him to propose that the AMPK cascade was a target for anti-diabetic drugs, a prediction later vindicated by the discovery that metformin activates the AMPK. Recently, Hardie identified the AMP-binding domains and their mutation in human disease and discovered that the tumour suppressor LKB1 is the "upstream" activator of AMPK. His work has opened up the AMPK system, which has become a major field of research with 400 papers per year being published and international conferences being held regularly on this topic.
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    Browse the records of some of our collections, which cover all branches of science and date from the 12th century onwards. These include the published works of Fellows of the Royal Society, personal papers of eminent scientists, letters and manuscripts sent to the Society or presented at meetings, and administrative records documenting the Society's activities since our foundation in 1660.

    Papers of Elsie Widdowson and Robert McCance
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