Record

RefNoEC/2008/32
LevelItem
TitlePearl, Laurence: certificate of election to the Royal Society
Date15 May 2008
DescriptionCertificate of Candidate for Election to the Fellowship
CitationLaurence Pearl has applied structural, biochemical and genetic techniques, to elucidate the molecular basis of function and specificity in systems of fundamental biomedical importance. His pioneering work on retroviral proteases was a key step in the recognition of HIV protease as a therapeutic target in AIDS. He has made seminal contributions to our understanding of the recognition and repair of DNA damage. In studies of the molecular chaperone Hsp90, he was the first to show its function depended on binding and hydrolysis of ATP, and he defined the mechanism of the ATPase-coupled molecular clamp that drives the chaperone cycle. In his research on cell signalling he has determined the structure of GSK3-beta, showing how it recognises substates, and elucidating how it is inhibited through insulin signalling.
Extent4p
AccessStatusClosed
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    Browse the records of some of our collections, which cover all branches of science and date from the 12th century onwards. These include the published works of Fellows of the Royal Society, personal papers of eminent scientists, letters and manuscripts sent to the Society or presented at meetings, and administrative records documenting the Society's activities since our foundation in 1660.

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