| Citation | Graham Russell's research on tissue mineralization and pyrophosphate set the scene for the discovery of bisphosphonates as drugs. He was a leader in that discovery process and in research that led to the application and use of the first generation bisphosphonates. Subsequently his work revealed a novel pathway of action of the nitrogen-containing bisphosphonates that has provided new therapeutic opportunities. He brought novelty to this field at its very beginning, and again almost 30 years later, with his work on the mechanism of action of these drugs, which are now the major drugs used for treating disorders of bone resorption. |