Description | Christine Holt is distinguished for her fundamental studies of axon guidance and topographic mapping in the visual system. She initiated the analysis of guidance and mapping in living embryos. She demonstrated the accurate targeting of the earliest retinal axons, and pioneered the dynamic imaging of axons and growth cones. She revealed the molecular basis of pathway choice at the chiasm, demonstrated the context dependent response of growth cones to guidance molecules and showed that local protein synthesis and degradation are essential to growth cone steering,. She has identified the molecular basis for the dorso-ventral axis of Sperry's retinotectal map. |