Citation | Todd is distinguished for his research on the genetics of common complex disease. In work spanning 20 years, he has pioneered theoretical and experimental approaches that have allowed him to resolve many aspects of the inheritance of type 1 diabetes. His elucidation of the molecular basis of the major gene effect in type 1 diabetes, together with his results from genome-wide analyses, have recently culminated in his successful dissection of the genetic architecture of type 1 diabetes, revealing a multiplicity of susceptibility genes converging on an aetiology of common, quantitative alterations in immune regulation. |